Diastereo- and Enantioselective Syntheses of Trisubstituted Benzopyrans by Cascade Reactions Catalyzed by Monomeric and Polymeric Recoverable Bifunctional Thioureas and Squaramides
journal contributionposted on 05.12.2018, 09:13 by José M. Andrés, Alicia Maestro, María Valle, Isabel Valencia, Rafael Pedrosa
4-Vinylphenyl-substituted squaramides have been tested as organocatalysts for the diastereo- and enantioselective synthesis of trisubstituted benzopyrans via an oxa-Michael intramolecular nitro-Michael cascade reaction. Both the enantio- and diastereoselection were good to moderate, depending on the nature of the chiral scaffold in the catalyst. The diastereoselection is better for the most active catalyst because the final products epimerize at C-3 along the time. Supported squaramide sq-9 prepared by copolymerization of sq-4 with styrene and divinylbenzene is also effective in promoting the cascade reaction, and it is recoverable and reusable for five cycles maintaining the activity.
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products epimerizeSquaramides 4- Vinylphenyl-substituted squaramidesoxa-Michael intramolecular nitro-Michael cascade reactionDiastereoMonomericC -3cascade reactionPolymeric Recoverable Bifunctional Thioureascopolymerizationchiral scaffolddiastereoselectiondiastereoCascade Reactions CatalyzedTrisubstituted Benzopyransnaturestyrenecatalystenantioselective synthesisEnantioselective Synthesesdivinylbenzeneorganocatalysttrisubstituted benzopyrans