posted on 2018-02-21, 00:00authored byWei Hao, Johannes H. Harenberg, Xiangyu Wu, Samantha N. MacMillan, Song Lin
We report a stereoselective
formal [3 + 2] cycloaddition of cyclopropyl
ketones and radical-acceptor alkenes to form polysubstituted cyclopentane
derivatives. Catalyzed by a chiral Ti(salen) complex, the cycloaddition
occurs via a radical redox-relay mechanism and constructs two C–C
bonds and two contiguous stereogenic centers with generally excellent
diastereo- and enantioselectivity.