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Development of the “Diverted Heck” Reaction for the Synthesis of Five-Membered Rings

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journal contribution
posted on 11.03.2021, 17:46 by Kevin Breitwieser, Peter Chen
The “diverted Heck” reaction has been shown to be a potent method to synthesize cyclopropanes from electron-rich olefins and iodomethyl trifluoroborate. Nevertheless, it is not mechanistically limited to the three-membered rings. The synthesis of five-membered rings using bifunctional substrates with a halide moiety and an organometallic group is described. Furthermore, the reactions of the respective boron and tin-based substrates are further investigated and optimized.