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Development of an Open-Air and Robust Method for Large-Scale Palladium-Catalyzed Cyanation of Aryl Halides: The Use of i-PrOH to Prevent Catalyst Poisoning by Oxygen

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journal contribution
posted on 17.07.2009, 00:00 by Yunlai Ren, Zhifei Liu, Shebin He, Shuang Zhao, Jianji Wang, Ruiqi Niu, Weiping Yin
Palladium-catalyzed cyanation of aryl halides is an often capricious reaction and lacks robustness due to catalyst poisoning by oxygen. In this report, an open-air and robust method for large-scale cyanation was developed and the use of commercially available i-propanol as an additive was critical for achieving the open-air, robust and scaleable process. Under the protection by i-propanol, the catalyst life was significantly prolonged.