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Development of a Suzuki Cross-Coupling Reaction between 2‑Azidoarylboronic Pinacolate Esters and Vinyl Triflates To Enable the Synthesis of [2,3]-Fused Indole Heterocycles

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journal contribution
posted on 17.12.2015, 01:09 by Navendu Jana, Quyen Nguyen, Tom G. Driver
The scope and limitations of a Suzuki reaction between 2-azidoarylboronic acid pinacolate esters and vinyl triflates are reported. This cross-coupling reaction enables the regioselective synthesis of indoles after a subsequent RhII2-catalyzed sp2-C–H bond amination reaction.