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Development of a Concise and Diversity-Oriented Approach for the Synthesis of Plecomacrolides via the Diene−Ene RCM

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journal contribution
posted on 16.03.2006, 00:00 by Kui Lu, Mengwei Huang, Zheng Xiang, Yongxiang Liu, Jiahua Chen, Zhen Yang
A concise synthesis of the core structures of plecomacrolide with ring sizes varying from 16 to 19 atoms was achieved for the first time by the diene−ene ring-closing olefin metathesis reaction. This approach should allow access to the structurally diverse analogues of plecomacrolide.