posted on 2011-09-02, 00:00authored byShohei Iyoshi, Masayasu Taki, Yukio Yamamoto
A cholesterol-conjugated fluorescence Zn2+ sensor based on the fluorescein platform was designed and synthesized. The cholesterol moiety is essential for localizing the Zn2+ sensor to the cell membrane, allowing the sensor to probe changes in the Zn2+ concentration in a localized area of the cell.