American Chemical Society
ol201746p_si_001.pdf (10.2 MB)

Development of a Cholesterol-Conjugated Fluorescent Sensor for Site-Specific Detection of Zinc Ion at the Plasma Membrane

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journal contribution
posted on 2011-09-02, 00:00 authored by Shohei Iyoshi, Masayasu Taki, Yukio Yamamoto
A cholesterol-conjugated fluorescence Zn2+ sensor based on the fluorescein platform was designed and synthesized. The cholesterol moiety is essential for localizing the Zn2+ sensor to the cell membrane, allowing the sensor to probe changes in the Zn2+ concentration in a localized area of the cell.