Development of a Cholesterol-Conjugated Fluorescent Sensor for Site-Specific Detection of Zinc Ion at the Plasma Membrane

Iyoshi, Shohei; Taki, Masayasu; Yamamoto, Yukio

doi:10.1021/ol201746p.s001

ol201746p_si_001.pdf (10.2 MB)

Development of a Cholesterol-Conjugated Fluorescent Sensor for Site-Specific Detection of Zinc Ion at the Plasma Membrane

journal contribution

posted on 2011-09-02, 00:00 authored by Shohei Iyoshi, Masayasu Taki, Yukio Yamamoto

A cholesterol-conjugated fluorescence Zn²⁺ sensor based on the fluorescein platform was designed and synthesized. The cholesterol moiety is essential for localizing the Zn²⁺ sensor to the cell membrane, allowing the sensor to probe changes in the Zn²⁺ concentration in a localized area of the cell.