American Chemical Society
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Development of Co- and Post-Translational Synthetic Strategies to C-Neoglycopeptides

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journal contribution
posted on 2002-09-24, 00:00 authored by Glenn J. McGarvey, Tyler E. Benedum, Frank W. Schmidtmann
The synthesis of stable, C-linked analogues of glycopeptides is being investigated with two complementary synthetic strategies, co-translational and post-translational glycopeptide synthesis. The key feature of the present approach lies in an effective olefin cross-metathesis reaction that allows formation of both glycoamino acids and glycopeptides.