op0c00185_si_001.pdf (265.77 kB)

Development and Execution of a Production-Scale Continuous [2 + 2] Photocycloaddition

Download (265.77 kB)
journal contribution
posted on 27.05.2020, 22:07 by Matthew G. Beaver, En-xuan Zhang, Zhi-qing Liu, Song-yuan Zheng, Bin Wang, Jiang-ping Lu, Jian Tao, Miguel Gonzalez, Siân Jones, Jason S. Tedrow
This article details the approach to large-scale production of cyclobutane 2 by the continuous-flow [2 + 2] photocycloaddition of maleic anhydride and ethylene, including (1) focused reaction optimization and development of a robust isolation protocol, (2) the approach to equipment design and process safety, and (3) the results of commissioning tests and production runs delivering the target compound at throughputs exceeding 5 kg/day.