ie501000k_si_001.pdf (377.15 kB)
Determination of Solubility of cAMPNa in Water + (Ethanol, Methanol, and Acetone) within 293.15–313.15 K
journal contribution
posted on 2014-07-02, 00:00 authored by Pengpeng Yang, Qingshi Wen, Jinglan Wu, Wei Zhuang, Yuehui Zhang, Hanjie YingThe
solubility of adenosine 3′,5′-cyclic monophosphate
sodium (cAMPNa) in mixed solvents (water+ethanol, water+methanol,
and water+acetone) was measured within 293.15−313.15 K under
atmospheric pressure. The (CNIBS)/Redlich−Kister model and
the modified Apelblat equation were respectively applied to correlate
the solubility data to evaluate the effect of the compositional ratio
of the organic solvent and the temperature on the solubility in binary
solvents, and satisfactory simulation results were obtained. The solubility
of cAMPNa was maximal in pure water and markedly diminished at all
evaluated temperatures as the mole fraction of the organic solvent
in the aqueous mixture increased. The thermodynamic functions for
cAMPNa dissolution in the three solvent mixtures were obtained from
the solubility data using the van’t Hoff and Gibbs equations,
and the dissolution behavior was discussed. Dissolution of cAMPNa
was endothermic and nonspontaneous in all cases, and the enthalpy
was the major contributing force to the Gibbs energy.