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Detection and Isolation of Dendritic Cells Using Lewis X‑Functionalized Magnetic Nanoparticles

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posted on 2016-02-20, 09:36 authored by Sara H. Rouhanifard, Ran Xie, Guoxin Zhang, Xiaoming Sun, Xing Chen, Peng Wu
dendritic cell (DC)-specific intracellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) is a receptor found on DCs that recognizes antigens bearing mannose-rich or fucosylated glycans, including Lewis X (LeX). Here, we report the fabrication of magnetic nanoparticles coated with multivalent LeX glycans using Cu (I)-catalyzed azide–alkyne cycloaddition. The resulting nanoparticles are selective and biocompatible, serving as a highly efficient tool for DC detection and enrichment.

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