cs8b03292_si_001.pdf (11.32 MB)
Download file

Design of Efficient Chiral Bifunctional Phase-Transfer Catalysts Possessing an Amino Functionality for Asymmetric Aminations

Download (11.32 MB)
journal contribution
posted on 27.11.2018, 00:00 by Suva Paria, Qi-Kai Kang, Miho Hatanaka, Keiji Maruoka
An efficient, chiral bifunctional phase-transfer catalyst with an intramolecular amino functionality has been designed and successfully applied to highly enantioselective amination of 3-aryloxindoles and 3-arylbenzofuran-2­(3H)-ones with bis­(adamantyl) azodicarboxylate. Optically active amination products were generally obtained in high yield with high enantioselectivity. The origin of stereoselectivity was explained by means of the DFT calculations.

History