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Design and Synthesis of a Cyclic Double Mutant Peptide (cyclo(87−99)[A91,A96]MBP87−99) Induces Altered Responses in Mice after Conjugation to Mannan: Implications in the Immunotherapy of Multiple Sclerosis

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posted on 08.01.2009, 00:00 by Maria Katsara, George Deraos, Theodore Tselios, Minos-Timotheos Matsoukas, Irene Friligou, John Matsoukas, Vasso Apostolopoulos
Altered peptide ligands that alter immune responses are a promising approach to the immunotherapy of multiple sclerosis. Cyclic peptides are of interest because the limited stability of linear peptides restricts their use in vivo. We designed and synthesized a cyclic double mutant peptide from MBP87−99-[cyclo(87−99)[A91,A96]MBP87−99]. Immunization of mice, in CFA reduced Th1 responses. However, when conjugated to reduced mannan, a significant further reduction of Th1 responses and moderate Th2 responses were induced.

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