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Design and Implementation of an Efficient Synthetic Approach to Furanosylated Indolocarbazoles:  Total Synthesis of (+)- and (−)-K252a

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journal contribution
posted on 15.10.1997, 00:00 by John L. Wood, Brian M. Stoltz, Hans-Jürgen Dietrich, Derek A. Pflum, Dejah T. Petsch
The first total synthesis of the natural product (+)-K252a (2) has been achieved in 12 steps from commercially available materials, with a longest linear sequence of seven steps and an overall yield of 21%. The synthetic strategy employs novel rhodium carbenoid chemistry in the construction of both the indolocarbazole aglycon (4) and the carbohydrate moiety (9).