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Download fileDesign and Application of Hybrid Phosphorus Ligands for Enantioselective Rh-Catalyzed Anti-Markovnikov Hydroformylation of Unfunctionalized 1,1-Disubstituted Alkenes
journal contribution
posted on 2018-03-30, 00:00 authored by Cai You, Shuailong Li, Xiuxiu Li, Jialing Lan, Yuhong Yang, Lung Wa Chung, Hui Lv, Xumu ZhangA series
of novel hybrid phosphorus ligands were designed and applied
to the Rh-catalyzed enantioselective anti-Markovnikov hydroformylation
of unfunctionalized 1,1-disubstituted alkenes. By employing the new
catalyst, linear aldehydes with β-chirality can be prepared
with high yields and enantioselectivities under mild conditions. Furthermore,
catalyst loading as low as 0.05 mol % furnished the desired product
in good yield and undiminished selectivity, demonstrating the efficiency
of this transformation in large-scale synthesis.
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seriesphosphorus ligandscatalyst loadingApplicationyieldRh-catalyzed enantioselective anti-Markovnikov hydroformylationAlkeneUnfunctionalized0.05aldehydeunfunctionalizedtransformationenantioselectivitiealkeneDisubstitutedefficiencymolselectivityHybrid Phosphorus LigandsdisubstitutedEnantioselective Rh-Catalyzed Anti-Markovnikov Hydroformylationβ- chiralitysynthesis