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Design, Synthesis, and Evaluation of the Antiproliferative Activity of a Series of Novel Fused Xanthenone Aminoderivatives in Human Breast Cancer Cells

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journal contribution
posted on 05.04.2007, 00:00 by Vasiliki Giannouli, Ioannis K. Kostakis, Nicole Pouli, Panagiotis Marakos, Olga Ch. Kousidou, George N. Tzanakakis, Nikos K. Karamanos
Derivatives of two novel, structurally related heterocyclic ring systems, xantheno[3,4-d]imidazole and chromeno[4,3,2-c,d]imidazo[4,5-f]indazole, bearing aminoalkyl side chains, have been synthesized, and their antiproliferative activity has been studied against the aggressive human breast MDA-MB-231 cell line. The pyrazole-fused analogue 27a possesses a pronounced antiproliferative effect on the tested cell line, evident at 1 μM, and achieves an IC50 of 6.5 μM.