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Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5‑HT2C Receptor Agonists

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journal contribution
posted on 12.03.2015, 00:00 authored by Guy Rouquet, Dianna E. Moore, Malcolm Spain, Daniel M. Allwood, Claudio Battilocchio, David C. Blakemore, Paul V. Fish, Stephen Jenkinson, Alan S. Jessiman, Steven V. Ley, Gordon McMurray, R. Ian Storer
A series of pyrido­[3,4-d]­azepines that are potent and selective 5-HT2C receptor agonists is disclosed. Compound 7 (PF-04781340) is identified as a suitable lead owing to good 5-HT2C potency, selectivity over 5-HT2B agonism, and in vitro ADME properties commensurate with an orally available and CNS penetrant profile. The synthesis of a novel bicyclic tetrasubstituted pyridine core template is outlined, including rationale to account for the unexpected formation of aminopyridine 13 resulting from an ammonia cascade cyclization.