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Design, Synthesis, and Evaluation of Analogues of (+)-14-Normethyldiscodermolide

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journal contribution
posted on 20.01.2005, 00:00 by Amos B. Smith, B. Scott Freeze, Matthew J. LaMarche, Tomoyasu Hirose, Ignacio Brouard, Ming Xian, Kurt F. Sundermann, Simon J. Shaw, Mark A. Burlingame, Susan Band Horwitz, David C. Myles
The design, syntheses, and biological evaluation of nine totally synthetic analogues of the microtubule-stabilizing agent (+)-14-normethyldiscodermolide (2) are reported. Simplification at the C(21)−C(24) terminal diene and at the C(1)−C(5) lactone moieties reveals significant structure−activity relationships.

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