jo7b02004_si_001.pdf (7.42 MB)
Design, Synthesis, and Application of Polymer-Supported Silicon-Transfer Agents for Cross-Coupling Reactions with Organolithium Reagents
journal contribution
posted on 2017-09-20, 00:00 authored by Minh H. Nguyen, Kevin T. O’Brien, Amos B. SmithThe
initial design, synthesis, and validation of polymer-supported
siloxane transfer agents have been achieved that permit the direct
use of organolithium reagents in the palladium-catalyzed cross-coupling
reactions. Through rational design, two generations of polymer support
were developed that significantly simplify product purification and
the transfer agent recycling.