jo030192r_si_002.pdf (1.34 MB)

Derivatized Amino Acids Relevant to Native Peptide Synthesis by Chemical Ligation and Acyl Transfer

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journal contribution
posted on 28.11.2003, 00:00 by Derrick L. J. Clive, Soleiman Hisaindee, Don M. Coltart
Three amino acids were converted into the derivatives 5.2 (from glycine), 6.4a and 6.4b (from alanine), and 8.3a and 8.3b (from O-benzyl serine). These N-alkylated amino acids, which can be deprotected after conversion of the carboxyl into an amide, correspond to the general structure 2.1, a compound class of use in the study of peptide segment coupling by the ligation−acyl transfer method.