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Derisking Development by a Cocrystallization Screen of a Novel Selective Inhaled JAK-STAT inhibitor

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journal contribution
posted on 15.11.2018, 00:00 by Antonio Llinas, Rafael Barbas, Mercè Font-Bardia, Amir Smailagic, Rafel Prohens
The discovery and detailed characterization of several new solid forms of a novel selective inhaled JAK-STAT inhibitor are described. Using a holistic cocrystallization screen approach to explore its formulation landscape, we decrease the risk of future potential development failures due to a nonoptimal pharmacokinetic lung profile or undesired lung effects in humans.