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Delivery of Cargo with a Bioelectronic Trigger

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journal contribution
posted on 15.06.2018, 00:00 by Zahra Hemmatian, Elmira Jalilian, Sangeun Lee, Xenofon Strakosas, Ali Khademhosseini, Adah Almutairi, Su Ryon Shin, Marco Rolandi
Biological systems exchange information often with chemical signals. Here, we demonstrate the chemical delivery of a fluorescent label using a bioelectronic trigger. Acid-sensitive microparticles release fluorescin diacetate upon low pH induced by a bioelectronic device. Cardiac fibroblast cells (CFs) uptake fluorescin diacetate, which transforms into fluorescein and emits a fluorescent signal. This proof-of-concept bioelectronic triggered delivery may be used in the future for real-time programming and control of cells and cell systems.