ol6b02617_si_001.pdf (3.89 MB)
Dehydrosulfurative C–N Cross-Coupling and Concomitant Oxidative Dehydrogenation for One-Step Synthesis of 2‑Aryl(alkyl)aminopyrimidines from 3,4-Dihydropyrimidin‑1H‑2-thiones
journal contribution
posted on 2016-09-28, 16:53 authored by Nguyen
Huu Trong Phan, Hyeji Kim, Hyunik Shin, Hee-Seung Lee, Jeong-Hun SohnA method for the synthesis of 2-aryl(alkyl)aminopyrimidines
from
readily available 3,4-dihydropyrimidin-1H-2-thiones
(DHPMs) via dehydrosulfurative C–N cross-coupling and concomitant
oxidative dehydrogenation under a Pd/Cu catalytic system is described.
This reaction protocol provides unprecedented diversity of fully substituted
2-aryl(alkyl)aminopyrimidines in a single step from a wide range of
DHPMs and amine coupling partners.