Dehydrogenative Synthesis of Quinolines, 2‑Aminoquinolines, and Quinazolines Using Singlet Diradical Ni(II)-Catalysts
journal contributionposted on 28.01.2019, 00:00 authored by Gargi Chakraborty, Rina Sikari, Siuli Das, Rakesh Mondal, Suman Sinha, Seemika Banerjee, Nanda D. Paul
Simple, straightforward, and atom economic methods for the synthesis of quinolines, 2-aminoquinolines, and quinazolines via biomimetic dehydrogenative condensation/coupling reactions, catalyzed by well-defined inexpensive and easy to prepare singlet diradical Ni(II)-catalysts featuring two antiferromagnetically coupled singlet diradical diamine type ligands are described. Various polysubstituted quinolines, 2-aminoquinolines, and quinazolines were synthesized in moderate to good yields from different low-cost and readily accessible starting materials. Several control experiments were carried out to get insight into the reaction mechanism which shows that the nickel and the coordinated diamine ligands participate in a synergistic way during the dehydrogenation of alcohols.
Read the peer-reviewed publication
Nidehydrogenative2- aminoquinolinesinsightdehydrogenationDiradicalQuinazolinesinglet diradical diamine type ligandsmechanismSingletantiferromagneticallymethodsynthesisquinazolinematerialSeveral control experimentscondensationQuinolineDehydrogenativeAminoquinolineyieldVarious polysubstituted quinolinesSynthesibiomimetic