Dehydrative Allylation of α C(sp3)–H Bonds of Alkylamines with Allylic Alcohols
journal contributionposted on 21.05.2020, 16:40 by Yusuke Masuda, Misato Ito, Masahiro Murakami
Herein reported is a dehydrative coupling reaction of alkyl amines with allylic alcohols promoted by co-operation of photoredox and palladium catalysts. A range of homoallylic amines are efficiently synthesized. A mechanistic study suggests that an in situ generated carboxylic acid activates an allylic alcohol to facilitate its oxidative addition onto palladium.