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Download fileDegradable Gelatin-Based IPN Cryogel Hemostat for Rapidly Stopping Deep Noncompressible Hemorrhage and Simultaneously Improving Wound Healing
journal contribution
posted on 2020-07-30, 16:41 authored by Ying Huang, Xin Zhao, Zhiyi Zhang, Yongping Liang, Zhanhai Yin, Baojun Chen, Lang Bai, Yong Han, Baolin GuoBiodegradable cryogel wound dressing
which can stop deep noncompressible
hemorrhage and simultaneously promote wound healing is a highly promising
biomaterial in clinics. Here, we prepared a series of biodegradable
interpenetrating polymer network (IPN) dry cryogel hemostats by cryo-polymerization
of gelatin and dopamine. The IPN structure of cross-linked gelatin
and polydopamine endows the cryogels good injectability, robust mechanical
property, and shape memory property. The cryogels showed better whole
blood-clotting capacity and more blood cell and platelet adhesion
and activation than gauze and gelatin hemostatic sponge. The cryogels
present less blood loss and shorter hemostasis time than gauze and
gelatin hemostatic sponges in the mouse liver trauma model, rat liver
incision model, and rabbit liver cross incision model. Especially,
the hemostatic effect of the cryogel on deep narrow noncompressible
hemorrhage was determined by the rabbit liver defect deep narrow noncompressible
hemorrhage model. The cryogel rapidly stopped deep massive noncompressible
hemorrhage in the swine subclavian artery and vein complete transection
model. Besides, the component of polydopamine endows cryogels with
excellent antioxidant activity and NIR irradiation-assisted photothermal
antibacterial ability. Gelatin/dopamine cryogels were more effective
in promoting wound healing than Tegaderm films. The developed biodegradable
cryogels with a simple preparation process and low cost and which
can be easily carried and used present huge potential as novel wound
dressing for rapid hemostasis and promoting wound healing.
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gelatin hemostatic spongesnoncompressible hemorrhage modelNIR irradiation-assisted photothermalDegradable Gelatin-Based IPN Cryoge...rabbit liver defectswine subclavian arterygelatin hemostatic spongerat liver incision modelmouse liver trauma modelnoncompressible hemorrhageDeep Noncompressible Hemorrhagewound healinginterpenetrating polymer networkcryogel wound dressingnovel wound dressingshape memory property