Deglycobleomycin:  Solid-Phase
Synthesis and DNA Cleavage by the
Resin-Bound Ligand

Smith, Kenneth L.; Tao, Zhi-Fu; Hashimoto, Shigeki; Leitheiser, Christopher J.; Wu, Xihan; Hecht, Sidney M.

doi:10.1021/ol010293g.s001

Deglycobleomycin: Solid-Phase Synthesis and DNA Cleavage by the Resin-Bound Ligand

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posted on 2002-03-09, 00:00 authored by Kenneth L. Smith, Zhi-Fu Tao, Shigeki Hashimoto, Christopher J. Leitheiser, Xihan Wu, Sidney M. Hecht

A greatly improved solid-phase synthesis of deglycobleomycin using a Dde-based linker is reported. The resin-bound deglycobleomycin could be completely deblocked and assayed for DNA plasmid relaxation, sequence-selective DNA cleavage, and light production from a molecular beacon.

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Deglycobleomycin: Solid-Phase Synthesis and DNA Cleavage by the Resin-Bound Ligand

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