ol0c02215_si_001.pdf (2.88 MB)
Decarboxylative Cross-Coupling of Acyl Fluorides with Potassium Perfluorobenzoates
journal contribution
posted on 2020-08-01, 15:29 authored by Liyan Fu, Qiang Chen, Yasushi NishiharaWe
report the transition metal-free decarboxylative cross-coupling reactions
of acyl fluorides with potassium perfluorobenzoates. Compared with
traditional transition metal-catalyzed cross-couplings, this protocol
presents an extremely environmentally benign pathway to afford unsymmetrical
diaryl ketones. To install perfluorophenyl groups, this method highlights
highly selective, inexpensive, and nontoxic conditions. The reaction
system tolerates various functional groups in acyl fluorides. Remarkably,
all of the starting materials can be prepared from abundant carboxylic
acids and the reaction proceeds without any catalysts and additives.