Dabco as an Inexpensive and Highly Efficient Ligand for Palladium-Catalyzed Suzuki−Miyaura Cross-Coupling Reaction

An inexpensive and highly efficient Pd(OAc)₂/Dabco catalytic system has been developed for the cross-coupling of aryl halides with arylboronic acids. A combination of Pd(OAc)₂ and Dabco (triethylenediamine) was observed to form an excellent catalyst, which affords high TONs (turnover numbers; TONs up to 950 000 for the reaction of PhI and p-chlorophenylboronic acid) for Suzuki−Miyaura cross-coupling of various aryl iodides and bromides with arylboronic acids.