American Chemical Society
ol048907f_si_001.pdf (1.28 MB)

Dabco as an Inexpensive and Highly Efficient Ligand for Palladium-Catalyzed Suzuki−Miyaura Cross-Coupling Reaction

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journal contribution
posted on 2004-08-05, 00:00 authored by Jin-Heng Li, Wen-Jie Liu
An inexpensive and highly efficient Pd(OAc)2/Dabco catalytic system has been developed for the cross-coupling of aryl halides with arylboronic acids. A combination of Pd(OAc)2 and Dabco (triethylenediamine) was observed to form an excellent catalyst, which affords high TONs (turnover numbers; TONs up to 950 000 for the reaction of PhI and p-chlorophenylboronic acid) for Suzuki−Miyaura cross-coupling of various aryl iodides and bromides with arylboronic acids.