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DMSO as a Dual Carbon Synthon and Water as Oxygen Donor for the Construction of 1,3,5-Oxadiazines from Amidines

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journal contribution
posted on 03.05.2021, 14:05 by Yi Zhang, Jinqiang Kuang, Xuqiong Xiao, Lei Wang, Yongmin Ma
A selective and efficient synthesis of diaryl 1,3,5-oxadiazines was established for the first time from simple and readily available amidines in wet DMSO. DMSO was employed as a dual carbon synthon and water offered the oxygen atom to construct the oxadiazine ring. The reaction involved two new C–N and two new C–O bond formations.