ol403040g_si_001.pdf (1.76 MB)
DMF as Carbon Source: Rh-Catalyzed α‑Methylation of Ketones
journal contribution
posted on 2014-01-03, 00:00 authored by Yang Li, Dong Xue, Wei Lu, Chao Wang, Zhao-Tie Liu, Jianliang XiaoAn unprecedented Rh-catalyzed direct
methylation of ketones with N,N-dimethylformamide
(DMF) is disclosed.
The reaction shows a broad substrate scope, tolerating both aryl and
alkyl ketones with various substituents. Mechanistic studies suggest
that DMF delivers a methylene fragment followed by a hydride in the
methylation process.