Cytotoxic Spirostane-Type Saponins from the Roots of Chlorophytum borivilianum
journal contributionposted on 23.01.2009, 00:00 by Debabrata Acharya, Anne-Claire Mitaine-Offer, Nutan Kaushik, Tomofumi Miyamoto, Thomas Paululat, Jean-François Mirjolet, Olivier Duchamp, Marie-Aleth Lacaille-Dubois
Four new spirostane-type saponins named borivilianosides E−H (1−4) were isolated from an ethanol extract of the roots of Chlorophytum borivilianum together with two known steroid saponins (5 and 6). The structures of 1−4 were elucidated using mainly 2D NMR spectroscopic techniques and mass spectrometry. The cytotoxicity of borivilianosides F (2), G (3), and H (4) and three known compounds was evaluated using two human colon cancer cell lines (HT-29 and HCT 116).