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Cytotoxic Polyhydroxy-Isoprenoids from Neodidymelliopsis negundinis

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posted on 2024-02-14, 08:03 authored by Patcharee Pripdeevech, Sarunpron Khruengsai, Chutima Tanapichatsakul, Wael M. Afifi, Winnie Chemutai Sum, Kevin D. Hyde, Sherif S. Ebada
Fungal-derived natural products continue to play a pivotal role in the discovery of drug agents for human, veterinary, and general agricultural use. The fungus Neodidymelliopsis negundinis presents a significant saprobic ascomycete whose metabolites remained hitherto unstudied. Herein we report the isolation of eight unprecedented secondary metabolites named neodidymelliosides A and B (1 and 2), neodidymelliol A (3), and neodidymellioic acids A–E (48) produced by the submerged cultures of the fungus. Compound 1 proved to be the most active compound, with IC50 values ranging between 4.8 and 8.8 μM against KB3.1 (cervix), PC-3 (prostate), MCF-7 (breast), SKOV-3 (ovary), A431 (skin), and A549 (lung) cell lines. Compound 1 revealed significant inhibition of Staphylococcus aureus and Candida albicans biofilms.

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