Cytotoxic Diterpenoids from Croton argyrophylloides
journal contributionposted on 23.10.2009, 00:00 by Hélcio S. Santos, Francisco W. A. Barros, Maria Rose Jane R. Albuquerque, Paulo N. Bandeira, Claúdia Pessoa, Raimundo Braz-Filho, Francisco J. Q. Monte, Jose Henrique Leal-Cardoso, Telma L. G. Lemos
Two new diterpenes, 1 and 2, together with the known ent-15-oxo-kaur-16-en-18-oic acid (3), were isolated from the bark of Croton argyrophylloides. The structural characterization of 1 and 2 was determined on the basis of spectroscopic data interpretation. The cytotoxicity of each compound was evaluated against HL-60 (leukemia), MDAMB-435 (melanoma), SF-295 (glioblastoma), and HCT-8 (colon carcinoma) human tumor cell lines and against human peripheral blood mononuclear cells. The hemolytic potential in mouse erythrocytes was also tested for 1−3.