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Cytotoxic Cycloartane Triterpene Saponins from Actaea asiatica

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journal contribution
posted on 2006-10-27, 00:00 authored by Jingchun Gao, Feng Huang, Jinchao Zhang, Guoyuan Zhu, Mengsu Yang, Peigen Xiao
Three new 9,19-cycloartane triterpene glycosides, asiaticoside A (1), asiaticoside B (2), and 25-O-ethylcimigenol-3-O-β-d-xylopyranoside (3), together with cimiacemoside I (4), 25-O-acetylcimigenol-3-β-O-d-xyloside (5), and 25-anhydrocimigenol-β-O-d-xyloside (6) were isolated from the roots/rhizomes extract of Actaea asiatica, and their structures were established by spectroscopic methods (IR, HRESIMS, and NMR). Compounds 13, 5, and 6 had notable cytotoxicity against HepG2 and MCF-7 cancer cell lines.

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