Cytotoxic Cycloartane Triterpene Saponins from Actaea asiatica

Three new 9,19-cycloartane triterpene glycosides, asiaticoside A (1), asiaticoside B (2), and 25-O-ethylcimigenol-3-O-β-d-xylopyranoside (3), together with cimiacemoside I (4), 25-O-acetylcimigenol-3-β-O-d-xyloside (5), and 25-anhydrocimigenol-β-O-d-xyloside (6) were isolated from the roots/rhizomes extract of Actaea asiatica, and their structures were established by spectroscopic methods (IR, HRESIMS, and NMR). Compounds 1−3, 5, and 6 had notable cytotoxicity against HepG2 and MCF-7 cancer cell lines.