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Cytosporolides A−C, Antimicrobial Meroterpenoids with a Unique Peroxylactone Skeleton from Cytospora sp.

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posted on 2010-07-16, 00:00 authored by Yan Li, Subin Niu, Bingda Sun, Shuchun Liu, Xingzhong Liu, Yongsheng Che
Cytosporolides A−C (13), three caryophyllene-derived meroterpenoids with a unique peroxylactone skeleton, were isolated from cultures of the fungus Cytospora sp. Their structures were elucidated by NMR spectroscopy, and the absolute configuration of the 5,6-diol moiety in 1 was assigned using Snatzke’s method. Compounds 13 showed significant antimicrobial activity against the Gram-positive bacteria Staphylococcus aureus and Streptococcus pneumoniae.

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