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Download fileCymantrene–Triazole “Click” Products: Structural Characterization and Electrochemical Properties
journal contribution
posted on 2014-09-22, 00:00 authored by David
P. Day, Thomas Dann, David. L. Hughes, Vasily S. Oganesyan, Dietmar Steverding, Gregory G. WildgooseWe
report the first known examples of triazole-derivatized cymantrene
complexes (η5-[4-substituted triazol-1-yl]cyclopentadienyl)tricarbonylmanganese(I),
obtained via a “click” chemical synthesis, bearing a
phenyl, 3-aminophenyl, or 4-aminophenyl moiety at the 4-position of
the triazole ring. Structural characterization data using multinuclear
NMR, UV–vis, ATR-IR, and mass spectrometric methods are provided,
as well as crystallographic data for (η5-[4-phenyltriazol-1-yl]cyclopentadienyl)tricarbonylmanganese(I)
and (η5-[4-(3-aminophenyl)triazol-1-yl]cyclopentadienyl)tricarbonylmanganese(I).
Cyclic voltammetric characterization of the redox behavior of each
of the three cymantrene–triazole complexes is presented together
with digital simulations, in situ infrared spectroelectrochemistry,
and DFT calculations to extract the associated kinetic and thermodynamic
parameters. The trypanocidal activity of each cymantrene–triazole
complex is also examined, and these complexes are found to be more
active than cymantrene alone.