American Chemical Society
np5b00810_si_001.pdf (11.73 MB)

Cyclopenta[b]benzofuran and Secodammarane Derivatives from the Stems of Aglaia stellatopilosa

Download (11.73 MB)
journal contribution
posted on 2016-03-14, 10:29 authored by Nuraqilah Othman, Li Pan, Michele Mejin, Julian C. L. Voong, Hee-byung Chai, Caroline M. Pannell, A. Douglas Kinghorn, Tiong C. Yeo
Four new 2,3-secodammarane triterpenoids, stellatonins A–D (36), together with a new 3,4-secodammarane triterpenoid, stellatonin E (7), and the known silvestrol (1), 5‴-episilvestrol (2), and β-sitosterol, were isolated from a methanol extract of the stems of Aglaia stellatopilosa through bioassay-guided fractionation. The structures of the new compounds were elucidated using spectroscopic and chemical methods. The compounds were evaluated for their cytotoxic activity against three human cancer cell lines and for their antimicrobial activity using a microtiter plate assay against a panel of Gram-positive and Gram-negative bacteria and fungi.