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Cyclodextrin-Grafted Poly(vanillin) Antimicrobial Bio-Nanohoops via “Graft From” RAFT and Supramolecular Host–Guest Chemistry

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posted on 2024-11-27, 10:03 authored by Jun Li, Yaping Zhang, Feng Zhang, Rongmin Wang, Yufeng He, Pengfei Song
Microbial infections have been recognized as one of the most serious threats to healthcare and agriculture production, and it is still a great challenge to explore antimicrobial biomaterials with supramolecular self-assembling systems. To address this challenge, novel bionanohoops were fabricated via “graft from” reversible addition–fragmentation chain transfer (RAFT) and supramolecular host–guest chemistry. Admittedly, controllable grafting of vanillin-derived homopolymer (PVMAx) from β-cyclodextrin (β-CD) to synthesize β-cyclodextrin-grafted poly(vanillin methacrylate) (β-CD-g-PVMAx, x = 5, 35, 103) was calculated from 1H NMR integral area, and 2D NOESY demonstrated that the primary structured linear homopolymer chains (β-CD-g-PVMA5) were linked to each other by host–guest interactions. Additionally, GPC results illustrated that the secondary structured nanohoops ([β-CD-g-PVMA5]y, y = 38 or 364) were self-assembled in situ from β-CD-g-PVMA5 through supramolecular host–guest chemistry. Compared with stacking nanorods, nanohoops not only exhibited excellent antibacterial and antifungal activities but also presented good biocompatibility and better paint adhesion. Overall, we provided a valuable strategy that constructs antimicrobial bionanohoops by combining “graft from” RAFT and supramolecular host–guest chemistry for addressing microbial infections.

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