jo802471u_si_004.pdf (11.4 MB)

Cycloadditions of 1,1-Disubstituted Benzocyclobutenes Obtained by C(sp3)−H Activation

Download (11.4 MB)
journal contribution
posted on 20.02.2009, 00:00 by Manon Chaumontet, Pascal Retailleau, Olivier Baudoin
An efficient synthesis of polycyclic molecules has been performed by a sequence involving palladium-catalyzed C−H activation and [4 + 2] cycloaddition. The intermediate benzocyclobutenes underwent a microwave-enhanced electrocyclic ring-opening/cycloaddition process with complete torquoselectivity and diastereoselectivity.