posted on 2020-08-17, 10:33authored byMurtada
A. Oshi, Juho Lee, Muhammad Naeem, Nurhasni Hasan, Jihyun Kim, Hak Jin Kim, Eun Hee Lee, Yunjin Jung, Jin-Wook Yoo
In
this study, we developed oral core–shell nanoparticles
composed of curcumin nanocrystals in the core and chitosan/alginate
multilayers in the shell for inflammation-targeted alleviation of
ulcerative colitis (UC). The release rate of curcumin from the core–shell
nanoparticles was low at a pH mimicking the stomach and small intestine,
whereas it was higher at a pH mimicking the colon. Further, biodistribution
studies in the gastrointestinal tract of mice showed that distribution
of nanoparticles was significantly higher in the colon than that in
the stomach and small intestine. Quantitative analysis of drugs in
colonic tissues and confocal imaging of colons revealed preferential
accumulation of nanoparticles in inflamed tissues than that in healthy
tissues. In vivo anti-inflammatory studies revealed
that nanoparticles exhibit enhanced efficacy in alleviating inflammation-related
symptoms in a mouse colitis model. The results suggest that the core–shell
nanoparticles presented here can be exploited as efficient colon-targeted
drug delivery systems for UC therapy.