posted on 2024-06-11, 13:38authored byYifan Cui, Dezhi Yang, Qiulan Li, Zhongmei Peng, Zitao Zhong, Yuzhu Song, Qinqin Han, Yaling Yang
Nanozyme-mediated antioxidative therapy
is a promising star for
treating a myriad of important diseases through eliminating excessive
reactive oxygen species (ROS) such as O2·– and H2O2, a critical mechanism for inflammatory
bowel disease (IBD). This work provides a high biocompatibility iodine–copper–zinc
covalent doped carbon dots (Cu,Zn,I-CDs) with the catalase (CAT)-,
superoxide dismutase (SOD)- and glutathione peroxidase (GPx)-like
catalytic activities for treating ulcerative colitis (UC) by scavenging
overproduced ROS. We found that I dopant aids in counteracting the
positive charge at Cu,Zn dopants brought on by low pH, enabling Cu,Zn,I-CDs
to process strong triple antioxidant nanozyme activities rather than
Cu,Zn-CDs. Vitro experiments displayed that the Cu,Zn,I-CDs could
scavenge the excessive ROS to protect cellular against oxidative stress
and reduce the expression of proinflammatory cytokines, such as TNF-α,
IL-1β, and IL-6. In sodium dextran sulfate (DSS)-induced colitis
mice models, Cu,Zn,I-CDs with excellent biocompatibility could effectively
relieve the inflammation of the colon, containing the reduction of
the colon length, the damaged epithelium, the infiltration of inflammatory
cells, and upregulation of antioxidant genes. Therefore, the therapy
of Cu,Zn,I-CD antioxidant nanozymes is an effective approach and provides
a novel strategy for UC treatment.