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Cu(I) Catalyst in DMF:  An Efficient Catalytic System for the Synthesis of Furans from 2-(1-Alkynyl)-2-alken-1-ones

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journal contribution
posted on 2005-05-27, 00:00 authored by Nitin T. Patil, Huanyou Wu, Yoshinori Yamamoto
The cyclization of 2-(1-alkynyl)-2-alken-1-ones 1 proceeded very smoothly in the presence of alcohols 2 with a catalytic amount of Cu(I)Br in DMF at 80 °C, leading to the formation of highly substituted furans 3. The catalytic system reported herein is easy to handle, compared to the previously known system wherein the reaction between 1 and 2 needed to use moisture sensitive gold(III) chloride.