posted on 2005-05-27, 00:00authored byNitin T. Patil, Huanyou Wu, Yoshinori Yamamoto
The cyclization of 2-(1-alkynyl)-2-alken-1-ones 1 proceeded
very smoothly in the presence of alcohols 2 with a catalytic
amount of Cu(I)Br in DMF at 80 °C, leading to the formation
of highly substituted furans 3. The catalytic system reported
herein is easy to handle, compared to the previously known
system wherein the reaction between 1 and 2 needed to use
moisture sensitive gold(III) chloride.