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Cu(I)-Catalyzed Three-Component Cyclization for the Construction of Functionalized Thiazoles

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journal contribution
posted on 15.07.2020, 19:43 by Yajun Wang, Xiang Liu, Baofu Zhu, Pengfeng Guo, Yongyan Pei, Qiuxing He, Hua Cao
A novel and straightforward strategy for the synthesis of functionalized thiazoles from thioamides, ynals, and alcohols via a copper­(I)-catalyzed three-component reaction has been described. Through the formation of new C–S, C–N, and C–O bonds in one pot, it is easy to produce various valuable thiazoles fixed with aryl or heteroaryl groups. In addition, the reaction also exhibits other unique advantages, such as high step economics, good functional group tolerance, and good regioselectivity.