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CuI-Catalyzed Domino Process to 2,3-Disubstituted Benzofurans from 1-Bromo-2-Iodobenzenes and β-Keto Esters

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journal contribution
posted on 06.07.2007, 00:00 by Biao Lu, Bao Wang, Yihua Zhang, Dawei Ma
CuI-catalyzed coupling of 1-bromo-2-iodobenzenes with β-keto esters in THF at 100 °C leads to 2,3-disubstituted benzofurans. This domino transformation involves an intermolecular C−C bond formation and a subsequent intramolecular C−O bond formation process. Benzofurans with different substituents at the 5- and 6-position are accessible by employing the corresponding 1-bromo-2-iodobenzenes.