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CuBr-Catalyzed α‑Arylation and Aerobic Oxidative Dehydrogenative C–N Coupling for the Synthesis of Spiro[cyclohexane-1,12′-isoindolo[1,2‑b]quinazolin]-10′-one Derivatives

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journal contribution
posted on 30.03.2020, 22:29 by Fang Dong, Jian-Quan Liu, Xiang-Shan Wang
A copper-catalyzed approach was disclosed for C­(sp3)–C­(sp2) bond formation via an α-arylation of carbonyl, and the subsequent oxidative dehydrogenation coupling occurred to form a C­(sp3)–N bond, wherein O2 served as a green oxidant. This protocol provided a domino method for the synthesis of spiro­[cyclohexane-1,12′-isoindolo­[1,2-b]­quinazolin]-10′-ones containing a nitrogen-substituted quaternary carbon center.