Cu-Doped Carbon Dots as Catalysts for the Chemiluminescence Detection of Glucose
journal contributionposted on 2019-06-06, 08:13 authored by Yan Duan, Yijun Huang, Shengyu Chen, Weiyuan Zuo, Bingfang Shi
Development of metal-doped carbon dots (CDs) to effectively modulate their electronic properties and surface chemical reactivities is still in its early stage. In this paper, a facile solid-phase synthesis strategy was developed to synthesize Cu-doped CDs (Cu-CDs) using citric acid as the carbon source and Cu(NO3)2·3H2O as the dopant, respectively. The as-prepared Cu-CDs exhibited superior peroxidase-like activity to horseradish peroxidase and were stable under a wide range of pH and temperatures. Consequently, the Cu-CD-based chemiluminescence sensing was applied to sensitively detect glucose with a low detection limit of 0.32 μM, and the recoveries and the relative standard deviation of the serum sample are 87.2–112.2 and 8.16% (n = 6), respectively. Notably, the proposed chemiluminescence sensing was also successfully applied for label-free detection of glucose in complex biological samples, which envisioned its potential applications in clinical diagnosis and other analytical assays.
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label-free detectionglucosesurface chemical reactivitiesGlucose DevelopmentCu-CD-based chemiluminescencemetal-doped carbon dotsacidpH0.32 μ Mas-prepared Cu-CDsserum sampleapplicationCu-Doped Carbon DotsCatalystdeviationCu-doped CDsassaysolid-phase synthesis strategyChemiluminescence Detectioncarbon sourcehorseradish peroxidasedopantperoxidase-like activityrecoverydetection limitdiagnosis