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Cu-Catalyzed Direct C7 Sulfonylation of Indolines with Arylsulfonyl Chlorides

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journal contribution
posted on 24.12.2019, 19:05 by Changlei Zhi, Qiuling Wang, Shuang Liu, Yuting Xue, Linlin Shi, Xinju Zhu, Xin-Qi Hao, Mao-Ping Song
An efficient Cu-catalyzed direct sulfonylation of indolines with easily accessible sulfonyl chlorides has been realized under an air atmosphere via a chelation-assisted strategy. This protocol exhibits several unique characteristics, including broad substrate scope, good functional group tolerance, and operational convenience, which enable a regioselective access to a variety of C-7 functionalized indoline scaffolds in moderate to good yields. The mechanistic study reveals that the sulfonyl radical might be involved in this transformation.